Research in Dr. Graham’s laboratory focuses on two main themes: the biology of the human placenta and cancer progression. Research on the placenta conducted in his laboratory aims for a better understanding of the relationships between fetally-derived placental cells and maternal tissues and how disruption of such relationships can lead to diseases of pregnancy. Cancer studies in his laboratory have led his group to investigate mechanisms by which the local tumour microenvironment, and in particular hypoxia, contributes to malignant progression. These research areas are funded through grants from the Canadian Institutes of Health Research.